Analogs
Brulium lingvatabs, Domrid SR, Domrid suspension, Doprid tablets, Domidon, Motinol, Motinorm, Motorix, Motoricum, Nausilium, Domperidon Hexal, Domperidon – stoma.
pharmachologic effect
Domperidone (active ingredient) has an antiemetic effect, soothes hiccups. Increases muscle tone in the stomach and intestines, accelerates gastric emptying. Virtually no effect on gastric secretion.
Indications for use
Feeling of fullness in the stomach, bloating and pain in the epigastric region, belching, flatulence, nausea, vomiting, heartburn. A specific indication is nausea and vomiting caused by dopamine agonists when used in the treatment of Parkinson’s disease. Pediatric pathologies directly related to hernia and defect in the function of the lower esophageal sphincter.
Method of administration and dosage
Children under 12 years of age are prescribed 0.3 mg per 1 kg of body weight, repeating 3-4 times a day if necessary.
Adults and children over 12 years old with a body weight of 35 kg or more with chronic dyspepsia are prescribed 10 mg 3 times a day and, if necessary, before bedtime. If necessary, the indicated dose can be doubled.
With severe nausea and vomiting , a dose of 20 mg 3-4 times a day before meals and before bedtime is prescribed . The tablets are recommended to be taken 15-30 minutes before meals. When eating, the absorption of the drug decreases slightly. The maximum daily dose is 80 mg.
In renal insufficiency, it is recommended to reduce the frequency of taking the drug. The duration of the primary treatment is 4 weeks. After that, the patient’s condition should be assessed and a decision should be made on the need for further treatment.
Side effects
Usually well tolerated. There were isolated cases of intestinal spasms, which quickly pass. Allergic reactions (skin rash) are extremely rare.
Contraindications
Hypersensitivity to the drug. Do not apply medication if stimulation of gastric motility can be hazardous, for example in the gastro – intestinal bleeding, mechanical obstruction or perforation of one of the GIT.
It is also contraindicated in patients with prolactin-secretory pituitary tumor (prolactinoma). The drug should not be prescribed to patients with impaired liver function.
Overdose
Manifested by drowsiness, disorientation and extrapyramidal disorders, especially in children. There is no specific antidote. In case of an overdose, gastric lavage, the use of activated charcoal, patient observation, supportive and symptomatic therapy are recommended. For the correction of extrapyramidal disorders, anticholinergic drugs, antiparkinsonian or antihistamines with anticholinergic activity can be effective.