Analogs

Pharmakinase, Aktilize, Fibrinolysin, Metalize, Elaxim, Distreptase, Biostrepta, Urokinase Medak.

pharmachologic effect

Activates the fibrinolytic enzyme system, breaks down fibrin contained in blood clots, resulting in thrombolysis.

Indications for use

Embolism of the pulmonary artery and its branches; arterial thrombosis and peripheral arterial embolism with conservative treatment; thrombosis of superficial and deep veins of the extremities; acute myocardial infarction during the first 12 hours; blockage of the vessels of the retina of the eye. 

Method of administration and dosage

Streptokinase is administered intravenously by drip, and, if necessary, intravenously.

B / in generally administered in an initial dose of 250,000 ME (IE) in 50 ml of isotonic p – pa chloride for 30 minutes sodium (30 drops per minute). This dose usually causes the onset of lysis (dissolution) of the thrombus. Then continue the introduction of streptokinase at a dose of 100,000 IU per hour. The total duration of administration is, as a rule, 16-18 hours. Subsequent treatment is carried out with heparin and indirect anticoagulants.  

With extensive arterial and venous thrombosis   , long-term administration of streptokinase is sometimes necessary.

The introduction of streptokinase in / a is used in the acute period of myocardial infarction   (initial dose of 20,000 ME; maintenance dose – 2,000-4,000 ME per minute for 30-90 minutes). 

Treatment is carried out under the control of thrombin time and blood levels of fibrinogen (one of the blood clotting factors).

Side effects

Possible non-specific reactions to protein; headache, nausea, slight chills; allergic reactions; hematomas with intramuscular injections; bleeding after puncture (piercing with a needle). To prevent allergic reactions, it is recommended to inject 50 mg of prednisolone intravenously with streptokinase. 

Contraindications

Hemorrhagic diathesis, recent bleeding, severe hypertension, streptococcal sepsis, stomach ulcer, septic endocarditis, severe diabetes mellitus, pregnancy. The drug should be used with caution in severe liver and kidney diseases, with active tuberculosis.

Overdose

In case of overdose, massive bleeding occurs.