Analogs

Allopurinol Sandoz, Allopurinol – Lugal, Adenurik.

pharmachologic effect

Reduces the concentration of uric acid and helps to dissolve urates.

Indications for use

Treatment and prevention of gout and hyperuricemia of any origin, recurrent mixed oxalate – calcium kidney stones in the presence of hyperuricosuria, increased formation of urates due to enzymatic disorders, prevention of acute nephropathy with cytostatic and radiation therapy of tumors and leukemia, as well as with complete therapeutic fasting.

Dosage and administration

The dosage regimen of the drug is set individually, under the control of the concentration of urate and uric acid in the blood and urine. Adults ingestion – 100–900 mg per day, depending on the severity of the disease. The frequency of administration is 2–4 times a day after meals. Children under the age of 15 years – 10-20 mg / kg per day, or 100-400 mg per day. Maximum doses: with impaired renal function – 100 mg per day. An increase in the dose is possible in cases where, against the background of the therapy, an increased concentration of urates in the blood and urine remains.        

Side effects

Dyspepsia, diarrhea, nausea, vomiting, abdominal pain, stomatitis, hyperbilirubinemia, cholestatic jaundice, increased activity of hepatic transaminases and alkaline phosphatase, rarely hepatonecrosis, hepatomegaly, granulomatous hepatitis. 

Contraindications

Hypersensitivity to allopurinol. Severe impaired liver and kidney function. Pregnancy and lactation. Primary (idiopathic) hemochromatosis (or its presence in a family history). Allopurinol treatment is absolutely not indicated for asymptomatic hyperuricemia. Allopurinol treatment should not be started during an acute attack of gout.

Overdose

Symptoms . Nausea, vomiting, diarrhea, dizziness, oliguria.

Treatment . Forced diuresis, hemo – and peritoneal dialysis.