Analogs

Karbalex, Mezacar SR, Mezacar suspension, Mezacar tablets, Oxapine, Tegretol, Trileptal, Finlepsin, Finlepsin 200 retard, Finlepsin 400 retard, Zeptol, Carbamazepine‑Astrapharm, Carbamazepine‑Darnitsa, Carbamazepine‑Health, Carbamazepine‑Health forte, Carbamazepine-FS, Carbapine, Timonil 300 retard, Carbamazepine-FS 200 retard, Carbamazepine-FS 400 retard.

Pharmacological action

Carbamazepine has a pronounced anticonvulsant and moderate antidepressant effect, improves mood.

Indications for use

The drug is used for psychomotor epilepsy, large seizures, mixed and local forms. It is not effective enough for small seizures.

Dosage and administration method

Assign inside (during meals) for adults starting from 0.1 g (0.5 tablets) 2-3 times a day, gradually increasing the dose to 0.8-1.2 g (4-6 tablets) per day. Average daily dose for children it is 20 mg per 1 kg of body weight, i.e. on average under 1 year of age – from 0.1 to 0.2 g per day; from 1 year to 5 years – 0.2-0.4 g; from 5 to 10 years – 0.4-0.6 g; from 10 to 15 years old – 0,6-1 g per day.

It can be prescribed in combination with other antiepileptic drugs.

Side effects

The drug is usually well tolerated. In some cases, loss of appetite, nausea, rarely – vomiting, headache, drowsiness, ataxia, accommodation disorders are possible. A decrease or disappearance of side effects occurs when the drug is temporarily discontinued or the dose is reduced.

Contraindications

The drug is contraindicated in cases of cardiac conduction disorders, liver damage.

Overdose

Symptoms Depression of the central nervous system functions up to coma, disorientation, drowsiness, agitation, hallucinations, a feeling of “fog” in front of the eyes, dysarthria, nystagmus, ataxia, dyskinesia, hyperreflexia changing to hyporeflexia, convulsions, psychomotor disorders, myoclonus, hypothermia, mydriasis; respiratory depression, pulmonary edema; tachycardia, decrease or increase in blood pressure, cardiac conduction disorders with expansion of the QRS complex, cardiac arrest .

Treatment. There is no specific antidote. Gastric lavage, administration of activated charcoal, hospitalization, symptomatic therapy. Forced diuresis, hemodialysis, and peritoneal dialysis are ineffective. It is recommended to perform hemosorption on carbon sorbents.