Analogs

Valprokom 300 chrono, Valprokom 500 chrono, Valproate Orion, Viprat, Gabagamma, Gabalept, Gabantin 300, Gabapentin, Keppra, Konvulex, Konvulsofin, Lamictal, Lamotrin 25, Lamotrin 50, Lamotrin 100, Latrigil, Lamitor, Lamitrilici, Levitrile Levicitam 500, Levicitam oral solution, Levetiracetam lupine, Lyrica, Meditan, Neuralgin, Neogabin 150, Neogabin 75, Noreg, Tebantin, Topamax, Topilex, Topilepsin, Topiramine, Topiromax 100, Topiromax 25, Encorat chrono, Epileptal, Eptalmatal, Epileptyme 300 – Teva, Valproate 500 – Teva, Depacaine Chrono 300, Depacaine Enteric 300, Konvulex retard.

pharmachologic effect

Anticonvulsant, effective in various forms of epilepsy.

Indications for use

Generalized and minor epileptic seizures; focal seizures with simple and complex symptoms; convulsive syndrome in organic brain diseases; behavioral disorders associated with epilepsy; febrile seizures in children; tick in children.

Method of administration and dosage

Adults and adolescents – a daily dose of 20-30 mg / kg of body weight; to achieve a stable clinical effect, the dose can be increased by 200 mg per day with an interval of 3-4 days; the highest daily dose is 50 mg / kg. Inside take with meals 2-3 times a day.      

For newborns and young children, the dose is selected individually: the daily dose is usually 30 mg / kg; the frequency of admission in children under the age of 1 year – 2 times, in older children – 3 times a day.       

Side effects

Nausea, vomiting, diarrhea, impaired liver and pancreas function, isolated stuporous state, ataxia, tremor, skin rash, angioedema, anemia, thrombocytopenia, prolonged bleeding time, leukopenia, rarely – alopecia, increased appetite, weight gain, amenorrhea and menstrual irregularities. 

Contraindications

Hypersensitivity to valproate; dysfunction of the liver and pancreas, hemorrhagic diathesis, pregnancy and lactation, age up to 3 years.

Overdose

Clinical manifestations of acute massive overdose usually occur in the form of coma of varying degrees with muscle hypotonia, hyporeflexia, miosis, and respiratory depression.