Analogs
Canavit .
pharmachologic effect
Hemostatic agent. It activates a specific carboxylase, which ensures the carboxylation of glutamic acid residues in the structure of proteins, thereby facilitating the synthesis of blood coagulation factors (II, VII, IX, X). The action develops 12-18 hours after administration.
Indications for use
Bleeding and hypoprothrombinemia , capillary and parenchymal bleeding, surgical interventions and wounds, ulcerative bleeding, severe symptoms of acute radiation sickness, nose and hemorrhoidal bleeding. It is prescribed in the last month of pregnancy in order to prevent bleeding in newborns, as well as for hemorrhagic phenomena in premature babies, uterine premenopausal and juvenile bleeding, with spontaneous bleeding, preparation for surgery, with the danger of bleeding in the postoperative period, with hemoptysis (pulmonary tuberculosis), hemorrhagic phenomena against the background of septic diseases. In addition, the indications for the appointment of menadione are bleeding and hypoprothrombinemia caused by an overdose of phenylin , neodicumarin , and other anticoagulants – vitamin K antagonists.
Method of administration and dosage
Assign within 3-4 days, then take a break for 4 days. After a break, the reception is repeated for 3-4 days. The daily dose can be divided into 2-3 doses. Before the operation, accompanied by severe parenchymal bleeding, the reception is started 2-3 days before the operation. Prescribe in / m.
The daily dose for adults with intramuscular injection is 0.01–0.015 g. Doses for children: at the age of 1 year – 0.002–0.005 g each , up to 2 years old – 0.006 g, 3-4 years old – 0.008 g, 5– 9 years old – 0.01 g, 10-14 years old – 0.015 g.
Side effects
Thromboembolism.
Contraindications
Hypercoagulation , thromboembolism, hemolytic disease of the newborn. It is prescribed with caution during pregnancy.
Overdose
In case of overdose, in rare cases, hypervitaminosis K occurs, manifested by hyperprothrombinemia and hyperthrombinemia , hyperbilirubinemia ; in isolated cases, children develop toxicosis (poisoning), manifested by convulsions.