Analogs

Cardiomagnet , Cardiomagnet forte, Lospirin , Polocard , Trombo ACC, Asafen , Aspecard , Aspenorm , Aspirin cardio , Acecardin , Gosadal , Thrombolic – cardio , Magnikor , Combi – ASK 75, Acard , Cordiseave , Areplex .

pharmachologic effect

It has an antithrombotic effect.

Indications for use

To reduce the risk of: death in patients with suspected acute myocardial infarction; morbidity and mortality in patients with myocardial infarction; transient ischemic attacks (hereinafter – TIA) and stroke in patients with TIA; morbidity and mortality in stable and unstable angina pectoris; myocardial infarction in patients with high risk of cardio – vascular complications (diabetes, controlled hypertension) and in patients with multifactorial risk of developing cardio – vascular diseases (hyperlipidemia, obesity, smoking, advanced age). 

For prevention: thrombosis and embolism after vascular surgery; deep vein thrombosis and pulmonary embolism after prolonged immobilization (after surgery).

For secondary prevention of stroke.

Method of administration and dosage

The drug is taken orally 30-60 minutes before meals, without chewing, drinking plenty of fluids.

To reduce the risk of fatal outcome   in patients with suspected acute myocardial infarction apply the preparation in a dose of 100-300 mg per day. Within 30 days after a heart attack, continue taking a maintenance dose of 100-300 mg per day.  

For secondary prevention of stroke,   use the drug at a dose of 100–300 mg per day. 

To reduce the risk of TIA and stroke   in patients with TIA, use 100–300 mg per day. 

To reduce the risk of developing the disease and a lethal outcome   in patients with stable and unstable angina – 100-300 mg per day.  

To prevent thromboembolism after vascular surgery,   use the drug at a dose of 100-200 mg per day every day or 300 mg per day every other day.  

Side effects

Dyspepsia, epigastric pain and abdominal pain; gastrointestinal inflammation, erosive – ulcerative lesions of the gastrointestinal tract, which in rare cases may cause gastro – intestinal hemorrhage and perforation with the relevant laboratory parameters and clinical manifestations.

Hemorrhages can lead to acute and chronic posthemorrhagic anemia / iron deficiency anemia with corresponding laboratory manifestations and clinical symptoms such as asthenia, pallor of the skin, hypoperfusion .

Contraindications

Hypersensitivity to acetylsalicylic acid, other salicylates or any component of the drug; BA caused by the use of salicylates or substances with a similar effect, especially NSAIDs, in history; acute peptic ulcer; hemorrhagic diathesis; severe renal failure; severe liver failure; severe heart failure; III trimester of pregnancy.

Overdose

The toxic effect of salicylates is possible due to chronic intoxication that has arisen against the background of long-term therapy ( use of> 100 mg / kg per day for more than 2 days can cause toxic effects), as well as due to acute intoxication. Chronic salicylate poisoning can be latent. Moderate chronic intoxication with salicylates, or salicylism , is noted, as a rule, only after repeated doses of high doses.