Analogs

Pyroxicam Sofarma , Fedin – 20, Texamen – L, Ksefokam, Ksefokam rapid, Lorakam – 4, Lorakam – 8, Brexin, Pyroxicam – B.

pharmachologic effect

NSAIDs of the oxycam group, have anti-inflammatory, analgesic, antiplatelet and antipyretic effects.

Indications for use

Rheumatoid arthritis, rheumatism, osteoarthritis, ankylosing spondylitis, sciatica, gout, tendonitis, bursitis, ankylosing spondylitis (ankylosing spondylitis), lumbago, neuralgia, myalgia, traumatic inflammation of soft tissues, primary algomenorrhea, as antipyretic agents in infectious – inflammatory diseases.

Dosage and administration

Inside with rheumatoid arthritis, osteoarthritis and ankylosing spondylitis prescribed 10-30 mg once a day for a long time.  

In acute diseases of skeletal muscles – at a dose of 40 mg per day in one or more doses for 2 days, in the next 7-10 days – 20 mg per day.    

In the treatment of an acute attack of gout, the initial dose is 40 mg per day once in the first 2 days, then for 4-6 days – 40 mg once a day or 20 mg 2 times a day.     

With primary algodismenorrhea, treatment should be started when the first symptoms appear at an initial dose of 40 mg per day for 2 days. In the next 1-3 days – 20 mg in 1 dose.   

As an antipyretic agent , a dose of 10-20 mg per day is prescribed ; if necessary, to quickly achieve the effect in the first 2 days, 40 mg per day are prescribed with a subsequent dose reduction.  

In juvenile rheumatoid arthritis, it is prescribed once a day: for children weighing < 15 kg – 5 mg per day, 16–25 kg – 10 mg per day, 26–45 kg – 15 mg per day,> 46 kg – 20 mg day.               

Rectally prescribed in the form of suppositories, 10-40 mg 1-2 times a day. Externally in the form of a gel is applied to the affected areas (column of 5-10 mm) 3-4 times a day; an occlusive dressing is not applied.  

Side effects

Dizziness, headache, drowsiness, insomnia, depression, irritability, hallucinations, paresthesia, lethargy, mood changes; impaired renal function, interstitial nephritis, papillary necrosis, nephrotic syndrome; nausea, anorexia, abdominal pain, flatulence, constipation, diarrhea, erosive – ulcerative lesions of the digestive tract, bleeding and perforation of the digestive tract, impaired liver function; allergic reactions.

Contraindications

Hypersensitivity to piroxicam, erosive – ulcerative lesions of the digestive tract, aspirin asthma, liver or kidney failure, pregnancy and lactation, hemorrhagic diathesis, age up to 14 years, age over 65 years; for rectal administration – proctitis, paraproctitis, hemorrhoids. 

Overdose

Symptoms Visual impairment, drowsiness, coma, loss of consciousness.

Treatment. Gastric lavage, antacids, activated charcoal, symptomatic therapy.