pharmachologic effect

A drug that affects the metabolism of uric acid. An alkaloid isolated from the corms of an excellent colchicum ( Colchicum speciosum Stev. ). It has a pronounced analgesic and anti-inflammatory effect in an acute attack of gout.

Indications for use

Gout, gouty arthritis, recurrent disease (familial Mediterranean fever), Behcet’s disease, chondrocalcinosis, scleroderma, phlebitis (several forms), and inflammatory diseases in dental and ENT – practice.

Dosage and administration

Inside. The 1 – day treatment – 3 mg per day (one tablet in the morning and 2 in the evening tablet) in the 2 – nd and 3 – rd day – 2 mg per day (1 tablet morning and evening), 4 – and the following days – 1 tablet per day (in the evening). For the prevention of acute gouty arthritis – 1 mg per day (evening). The maximum daily dose is 8 mg.        

Side effects

Nausea, vomiting, abdominal pain, diarrhea, impaired renal function, leukopenia, agranulocytosis, measles rash, urticaria, alopecia.

Contraindications

Pregnancy and lactation; severe renal and / or liver failure; hypersensitivity to colchicine. Use with caution in elderly patients, with diseases of the kidneys, gastrointestinal tract, heart.

Overdose

Symptoms Burning and sore throat and mouth, urge to vomit and difficulty swallowing, nausea, thirst and vomiting, and then urge to urinate and defecate, tenesmus and colic. Neurological disorders manifest in the form of decreased sensitivity, seizures, and symptoms of paralysis. It may lead to death in the first three days due to cardio – vascular disease and respiratory paralysis. 

Treatment. Carried out only in the conditions of the toxicological center.