Cyanocobalamin – Darnitsa , Neurocobal .

pharmachologic effect

Cyanocobalamin is a vitamin B12. It activates the metabolism of carbohydrates, proteins and lipids, participates in the synthesis of labile methyl groups, in the formation of choline, methionine, nucleic acids, creatine, promotes the accumulation of compounds with sulfhydryl groups in erythrocytes. 

Indications for use

Treatment of malignant, post-hemorrhagic and iron deficiency anemias, aplastic anemias in children, alimentary anemias, as well as those caused by toxic substances and drugs, other anemias occurring with vitamin B12 deficiency, regardless of the reasons for the deficiency. Vitamin is indicated for polyneuritis, trigeminal neuralgia, radiculitis, causalgia, migraine, diabetic neuritis, amyotrophic lateral sclerosis, cerebral palsy, Down’s disease, alcoholic delirium. It is used for dystrophy, in newborns, including premature babies after infectious diseases, with sprue, liver diseases, radiation sickness, psoriasis, dermatitis herpetiformis, neurodermatitis, photodermatosis, etc.

Method of administration and dosage

Cyanocobalamin is administered subcutaneously, intramuscularly, intravenously and intralumbar .

In the treatment of Addison’s disease – Birmer   appoint 100-200 mcg per day every other day; for macrocytic anemia with neurological symptoms – 500 mcg or more per one injection (during the first week, every day, then with intervals between injections for 5-7 days).    

In case of post-hemorrhagic and iron deficiency anemias, Cyanocobalamin is prescribed 30–100 mcg 3 times a week; in the treatment of aplastic anemias – 100 mcg to clinical and hematological improvement.      

In the treatment of alimentary anemia in premature infants and young children, vitamin B12 is   prescribed at 30 mcg per day for 15 days. 

In neurological diseases and pathology of the central nervous system , 200–500 mcg per injection   is administered , with a gradual increase in dosages, and if the condition improves , the dose is reduced to 100 mcg per day. The course of therapy is 2 weeks.    

Traumatic lesions of peripheral nerves   used for 200-400 mcg every other day for 45 days. 

With cirrhosis of the liver and hepatitis – 30-60 mcg daily or 100 mcg every other day. The therapy is designed for 25-40 days.    

With Down’s disease, dystrophy in children, cerebral palsy – 15-30 mcg every other day.   

In the treatment of amyotrophic lateral sclerosis, funicular myelosis , multiple sclerosis, the   drug can be administered intralumbar at 15–30 mcg with increasing dosages up to 250 mcg.   

Side effects

With increased sensitivity to cyanocobalamin , allergic reactions, headache, dizziness, nervous agitation, pain in the heart, tachycardia may occur. In these cases, the use of the vitamin is temporarily stopped or canceled. If necessary, treatment with cyanocobalamin is resumed, starting with low doses (15-30 mcg). 


Erythremia, erythrocytosis, neoplasms, except for cases accompanied by megaloblastic anemia and vitamin B12 deficiency, thromboembolism. It is prescribed with caution to patients with angina pectoris.


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