pharmachologic effect

Antiplatelet agent.

Indications for use

Prevention of cerebrovascular and cardiovascular – vascular acute ischemic complications in patients with impaired cerebral and peripheral blood circulation. Prevention and correction of platelet dysfunctions caused by extracorporeal circulation during surgical interventions and hemodialysis. The use of Ipaton for the indicated indications is recommended primarily for patients with intolerance or allergy to acetylsalicylic acid or in case of ineffective treatment with it.

Method of administration and dosage

The usual dose for adults is 1 tablet 2 times a day with meals, without chewing, with a sufficient amount of liquid. In order to prevent occlusion after coronary stent implantation,   it is recommended to start treatment immediately before or immediately after stent implantation, 1 tablet 2 times a day in combination with 100–325 mg of acetylsalicylic acid per day. The duration of the combined treatment is at least 1 month.    

Side effects

Epistaxis, neutropenia, nausea and diarrhea; in the first 3 months of therapy – skin rashes.  

Contraindications

Hypersensitivity to the drug; hemorrhagic diathesis; blood diseases accompanied by an increase in bleeding time; organic lesions with a tendency to bleeding; leukopenia, thrombocytopenia and agranulocytosis; high-dose heparin treatment; liver disease; During pregnancy and breastfeeding; age up to 14 years. Cannot be used as a means of preventing thromboembolism in healthy patients.

Overdose

Symptoms   Overdose cases have not been described.

Treatment.   Remove from the body the remnants of the drug that has not yet been absorbed, induce vomiting, and rinse the stomach. Patients need close supervision. If bleeding occurs, desmopressin or platelet transfusion is prescribed to suppress the effect of the drug.