Analogs

Aponil, Mesulid, Nise, Nimegesic, Nimesil, Nimesin, Nimid gel, Nimid granules, Nimid tablets, Nimesulide – Darnitsa, Nimesulide – Phytopharm, Nimulid, Remesulid, Remisid, Toro – Sanovel, Affida Fort, Gel, Nimulid Nimid Forte, Nanogan, Oksigan, Shigan.

pharmachologic effect

In terms of anti-inflammatory activity at the initial stages of inflammation, it is comparable to Indomethacin and Piroxicam.

Indications for use

Acute pain syndrome. Symptomatic treatment of osteoarthritis with pain syndrome. Primary dysmenorrhea.

Method of administration and dosage

Apply the minimum effective dose for the shortest possible time to reduce side effects. It is advisable to take the drug before meals or 2 hours after meals. 

Adults and children over 14 years of age: The usual oral dose is 1 tablet (100 mg) 2 times a day. If necessary, the dose can be increased to 2 tablets 2 times a day.    

Children from 6 years old: 0.5 tablets (50 mg) 2 times a day. Children from 10 years old : 1 tablet 2 times a day. Elderly people do not need to adjust the dosage regimen.    

Side effects

Possible: gastralgia, nausea, diarrhea, dizziness, skin rash in the form of urticaria or erythema, changes in the blood: thrombocytopenia, leukopenia, anemia; increased activity of hepatic transaminases. These phenomena quickly disappear after discontinuation of the drug.

Contraindications

Hypersensitivity to nimesulide or to any component of the drug. History of hyperergic reactions due to the use of acetylsalicylic acid or other NSAIDs. History of hepatotoxic reaction to nimesulide. Peptic ulcer or duodenal ulcer exacerbation, recurrent peptic ulcer or gastro – intestinal bleeding, cerebrovascular bleeding or other conditions accompanied by bleeding. Significant bleeding disorder. Severe heart failure. Severe renal failure. Liver failure. Age up to 12 years. III trimester of pregnancy and lactation period. Fever and flu-like symptoms. Suspected acute surgical pathology. Alcoholism and drug addiction. 

Overdose

Symptoms Apathy, drowsiness, nausea, vomiting, epigastric pain. You may experience gastro – intestinal bleeding, hypertension, acute renal failure, respiratory depression, coma. However, such phenomena are rarely noted. 

Treatment . Symptomatic; there is no specific antidote. There are no data on the elimination of nimesulide by hemodialysis, but given the high degree of binding of nimesulide to blood plasma proteins (up to 97.5 %), it is unlikely that dialysis will be effective. Shows gastric lavage, the use of activated carbon.