Analogs
Thiocetam, Dipana, Livodex, Methionine, Molixan, Oktolipen, Resalut Pro, Silegon, Silibinin, Silimar, Thiolipon, Urdoxa, Ursodez, Ursodeoxycholic acid, Phosphoncial, Exhol, Essliver, T – Triomax.
pharmachologic effect
Anti-ischemic, membrane-stabilizing, antioxidant, reparative and immunomodulating drug.
Indications for use
Coronary heart disease, chronic hepatitis of various etiologies, alcoholic hepatitis, fibrosis and cirrhosis of the liver; angina pectoris, myocardial infarction, post-infarction cardiosclerosis, cardiac arrhythmias.
Dosage and administration
Tablets:
Stable angina pectoris : 200 mg orally 3 times a day, course of treatment – 8 weeks; angina pectoris, myocardial infarction, post-infarction cardiosclerosis : 200 mg orally 3 times a day for 20-30 days; heart rhythm disturbances : 200 mg inside or under the tongue 3 times a day; liver disease : 200 mg orally 3 times a day for 20-30 days.
P – p for injection:
Myocardial infarction, unstable angina pectoris : iv slowly 4 ml 25 mg / ml r – ra (100 mg) at a rate of 2 ml per minute or iv in a drop rate of 20-30 drops per minute (4 ml r – ra 25 mg / ml diluted in 150-250 ml of 0.9 % p – pa, or introduced into / m sodium chloride) to 4 ml of 25 mg / ml p – pa (100 , treatment mg) 2-3 times a day – 14 days; angina pectoris of tension and rest, post-infarction cardiosclerosis : i / m 2 ml 25 mg / ml p – ra 3 times a day, course of treatment – 20-30 days; chronic hepatitis with a pronounced activity of the process : in the first 5 days, 2 ml 25 mg / ml p – ra (50 mg) is injected 2–3 times a day or iv slowly at a rate of 2 ml per minute, 4 ml 25 mg / ml r – ra (100 mg) once a day, or drip at a rate of 20-30 drops per minute (2 ampoules of 25 mg / ml r – ra are diluted in 150-250 ml of 0.9 % sodium r – ra chloride) with 5 – th to 20 – day therapies are administered in tablets (100 mg 3 times a day); chronic hepatitis of minimal and moderate degree of activity : i / m 2 ml 25 mg / ml r – ra 3 times a day, the course of treatment – 20-30 days; cirrhosis of the liver : begin with a / m injection of 2 ml of 25 mg / ml r – ra (50 mg) 3 times a day for 5 days, and then continue treatment with tablets (100 mg 3 times a day), the course of treatment is 60 days.
The duration of the course of treatment is determined by the doctor.
Side effects
Itching, flushing of the skin, rash, hives, angioedema, anaphylactic shock, dizziness, tinnitus, headache, dry mouth, nausea, vomiting, bloating, shortness of breath, suffocation, fever, general weakness, increased blood pressure, heart palpitations.
Contraindications
Increased individual sensitivity to thiazoic acid and other components of the drug; renal failure.
Overdose
An increase in the concentration of sodium and potassium in the urine indicates an overdose and the need to cancel the drug. The treatment is symptomatic.