Gastril, Pirenzepine.

pharmachologic effect

Selectively inhibits the production of pepsinogen and hydrochloric acid by the glands of the stomach without significantly affecting the m – cholinergic receptors of the heart, salivary glands, eye muscles and other organs. The drug blocks the secretion of hydrochloric acid stimulated by histamine by 25 %, by 53 % by food intake, by 58 % by insulin.     

Indications for use

Stomach ulcers (acute and chronic); duodenal ulcers (acute and chronic); pylorospasm; duodenitis; esophagitis.

Method of administration and dosage

The daily dose of the drug in tablets   is from 50 to 150 mg. The average single dose is 50 mg. Gastrocepin is taken twice a day, 30 minutes before meals. The recommended duration of treatment is 1–1.5 months. – p of the   drug is injected intramuscularly or slowly into a vein twice a day in a single dose of 2 ml.     

Side effects

Dry mouth, mydriasis, headache, constipation, tachycardia, accommodation disorders, urinary retention, allergic reactions.


Glaucoma, prostatic hypertrophy, pregnancy and lactation.


Symptoms   Dry mouth, mydriasis, muscle twitching, tachycardia, delirium, chorea, athetosis, urinary retention.

Treatment.   Gastric lavage, activated carbon, in case of severe poisoning – intravenous administration of physostigmine. 

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