Analogs

Indomethacin – Health, Indomethacin – retard, Metindol retard.

pharmachologic effect

A drug with a pronounced analgesic, anti-inflammatory and antipyretic effect due to inhibition of prostaglandin synthesis. Inhibits platelet aggregation.

Indications for use

Rheumatism, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gout, muscle injuries – the locomotive system, neuralgia, myalgia, primary dysmenorrhea, as an auxiliary agent for inflammatory diseases ENT – organs.

Dosage and administration

Adults are prescribed by mouth 25-50 mg 2-3 times a day or rectally 50-100 mg 2 times a day; the daily dose should not exceed 150-200 mg. Children are prescribed at the rate of 2 mg per 1 kg of body weight per day in 3 divided doses. Retard – forms are prescribed orally 1-2 times a day.     

Side effects

Headache, dizziness, confusion, dyspeptic symptoms (abdominal pain, nausea, vomiting, diarrhea or constipation), ulcerogenic effects, allergic reactions, salt and water retention with a tendency to peripheral edema, in some cases myelosuppression, impaired renal function and liver. 

Contraindications

Gastric ulcer and duodenal ulcers, gastro – intestinal bleeding, severe heart, kidney or liver failure, malignant hypertension (AH), asthma and allergic reactions caused by acetylsalicylic acid or other non-steroidal anti-inflammatory drugs, hemorrhagic diathesis, radiation, pregnancy, lactation.

Overdose

Symptoms . Vomiting, severe headache, nausea, dizziness, disorientation, memory impairment; in severe cases – numbness of the limbs, convulsions. Symptomatic therapy is needed.