Azoprol retard, Betalok, Betalok ZOK, Corvitol 100, Corvitol 50, Logimaks, Metoprolol tartrate, Egilok, Vasocardin, Metoprolol zentiva, Egilok retard, Emzok.

pharmachologic effect

It has analgesic, antihypertensive and antiarrhythmic effects, reduces the automatism of the sinus node, inhibits AV ‑conduction, reduces myocardial inotropic function and heart rate. Reduces the number of angina attacks, reduces myocardial oxygen demand, increases exercise tolerance.

In myocardial infarction, it limits the zone of ischemia of the heart muscle and prevents heart rhythm disturbance.

Indications for use

AG; ischemic heart disease; stable or unstable angina; heart failure; heart rhythm disturbances; arrhythmias against the background of mitral valve prolapse; secondary prevention after myocardial infarction; functional disorders of cardiac activity, accompanied by tachycardia; hyperthyroidism; prevention of migraine attacks.

Dosage and administration

With hypertension and angina pectoris , the initial dose is 50 mg per day in 1 dose. The daily dose can be gradually increased to 100-200 mg in 1 dose. The drug can be used with other antihypertensive, antihypertensive and antianginal agents.

In heart failure , the initial dose is 25 mg per day. If necessary, every 2 weeks the dose can be increased to 50 mg, after another 2 weeks – up to 100 mg, if necessary after 2 weeks – up to 200 mg.

With arrhythmia , the initial dose is 50-200 mg per day in 1 dose.

In order to prevent recurrent myocardial infarction, the dose is selected individually.

For the prevention of migraine attacks, the usual dose is 100-200 mg per day in 1 dose. Prolonged-release tablets are taken 1 time per day, without chewing and drinking plenty of liquid.

The drug can also be taken with food or on an empty stomach.

Side effects

Decreased heart rate, blood pressure. Violation of AV ‑conduction, symptoms of heart failure, depression. Fatigue, headache, dizziness, sleep disturbance. In many cases, these phenomena disappear on their own with a decrease in the dose of the drug.


Hypersensitivity to the drug; AV ‑block II-III degree, severe sinus bradycardia, arterial hypotension, acute decompensated heart failure, severe peripheral circulatory disorders, cardiogenic shock, BA, sick sinus syndrome.


Symptoms . Severe hypotension, sinus bradycardia, AV ‑block, heart failure, cardiogenic shock, cardiac arrest, bronchospasm, impaired consciousness, coma, nausea, vomiting, and cyanosis. The simultaneous use of alcohol, drugs to lower blood pressure, quinidine or barbiturates can complicate the patient’s condition.

Treatment. Symptomatic therapy.

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