Zofran , Ondansetron , Osetron , Emeton , Emtron , Ondansetron Sandoz , Ondansetron – Teva , Emeset , Yunorm .
Has an antiemetic effect.
Indications for use
Nausea and vomiting caused by cytotoxic chemotherapy or radiation therapy; prevention and treatment of postoperative nausea and vomiting.
Method of administration and dosage
Prescribed parenterally and orally.
For emetogenic chemotherapy and radiation therapy, adults are prescribed at a dose of 8 mg IV slowly immediately before treatment or by mouth 1-2 hours before treatment, followed by 8 mg by mouth with an interval of 12 hours. Children can be prescribed as a single IV injection at a dose of 5 mg / m² immediately before chemotherapy, followed by oral administration at a dose of 4 mg 12 hours after injection. To prevent vomiting over the next 5 days, the drug is administered orally at 4 mg 2 times a day. For postoperative nausea and vomiting, adults can be administered orally at a dose of 16 mg 1 hour before anesthesia. Alternatively, 4 mg may be administered as a slow intravenous injection or intramuscularly during induction of anesthesia. Children can be given a dose of 0.1 mg / kg (up to a maximum of 4 mg) as a slow intravenous injection before, during or after induction of anesthesia. To eliminate the developed postoperative nausea and vomiting in children, the drug can also be prescribed in a dose of 0.1 mg / kg (up to a maximum of 4 mg) as a slow intravenous injection.
Headache, rarely – transient visual impairment and dizziness with rapid intravenous injection, seizures, involuntary movement disorders; immediate allergic reactions; chest pain, arrhythmia, hypertension, bradycardia; feeling warmth or flushing of the face, hiccups; sometimes – local reactions in the area of injection.
Hypersensitivity to the drug, I trimester of pregnancy and lactation.
In patients who received 84 or 145 mg of the drug intravenously, there were only minor side effects that did not require treatment.